CovidPublicV1, Main, Exploration, bibRecord, 000024

Variability of Salivary and Nasal Specimens for SARS-CoV-2 Detection.

Identifieur interne : 000024 ( Main/Exploration ); précédent : 000023; suivant : 000025

Variability of Salivary and Nasal Specimens for SARS-CoV-2 Detection.

Auteurs : Yukari C. Manabe ; Carolyn Reuland ; Tong Yu ; Razvan Azamfirei ; Taylor Church ; Diane M. Brown ; Thelio T. Sewell ; Justin P. Hardick ; Paul W. Blair ; Christopher D. Heaney ; Andrew Pekosz ; David L. Thomas

Source :

medRxiv : the preprint server for health sciences ; 2020.

RBID : pubmed:33052355

Abstract

In a large cohort of ambulatory confirmed COVID-19 patients with multiple self-collected sample time points, we compared 202 matched nasal-oropharyngeal swabs and oral salivary fluid sample pairs by RT-PCR. Nasal-oropharyngeal swabs were more sensitive than this salivary sample type (oral crevicular fluid) suggesting that not all saliva sample types have equivalent sensitivity. However, all samples that were Vero E6-TMPRSS2 cell culture positive (e.g., infectious virus) were also oral fluid RT-PCR positive suggesting that oral fluid may find the patients most likely to transmit disease to others.

DOI: 10.1101/2020.10.07.20208520
PubMed: 33052355
PubMed Central: PMC7553172

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">In a large cohort of ambulatory confirmed COVID-19 patients with multiple self-collected sample time points, we compared 202 matched nasal-oropharyngeal swabs and oral salivary fluid sample pairs by RT-PCR. Nasal-oropharyngeal swabs were more sensitive than this salivary sample type (oral crevicular fluid) suggesting that not all saliva sample types have equivalent sensitivity. However, all samples that were Vero E6-TMPRSS2 cell culture positive (e.g., infectious virus) were also oral fluid RT-PCR positive suggesting that oral fluid may find the patients most likely to transmit disease to others.</div>
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Variability of Salivary and Nasal Specimens for SARS-CoV-2 Detection.

Variability of Salivary and Nasal Specimens for SARS-CoV-2 Detection.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki